翻訳と辞書 Words near each other ・ Negative Burn ・ Negative cache ・ Negative campaigning ・ Negative capability ・ Negative carbon dioxide emission ・ Negative checking ・ Negative conclusion from affirmative premises ・ Negative consequentialism ・ Negative cost ・ Negative Creep ・ Negative cutting ・ Negative database ・ Negative Dialectics ・ Negative double ・ Negative edge ・ Negative elongation factor ・ Negative energy ・ Negative equity ・ Negative feedback ・ Negative feedback amplifier ・ Negative flag ・ Negative Format ・ Negative free bid ・ Negative freeroll ・ Negative frequency ・ Negative FX ・ Negative FX (album) ・ Negative gearing ・ Negative hyperconjugation ・ Negative hypergeometric distribution Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Negative elongation factor ： ウィキペディア英語版 Negative elongation factor In molecular biology, NELF (negative elongation factor) is a four-subunit protein (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively impacts transcription by RNA polymerase II (Pol II) by pausing about 20-60 nucleotides downstream from the transcription start site (TSS). ==Structure== The NELF-A subunit is encoded by the gene WHSC2 (Wolf-Hirschhorn syndrome candidate 2). Microsequencing analysis demonstrated that NELF-B was the protein previously identified as the protein encoded by the gene COBRA1, and was shown to interact with BRCA1. It is unknown whether or not NELF-C and NELF-D are peptides resulting from the same mRNA with different translation initiation sites, possibly differing only in an extra 9 amino acids for NELF-C at the N-terminus, or peptides from different mRNAs entirely. A single NELF complex consists of either NELF-C or NELF-D but not both. NELF-E is also known as RDBP.〔 NELF binds in a stable complex with DSIF and RNA polymerase II together, but not with either alone. P-TEFb (positive transcription elongation factor b) inhibits the effect of NELF and DSIF on Pol II elongation, via its phosphorylation of serine-2 of the C-terminal domain of Pol II, and the SPT5 subunit of DSIF, causing dissociation of NELF.〔 NELF homologues exist in some metazoans (e.g. insects and vertebrates) but have not been found in plants, yeast, or nematode (worms).〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Negative elongation factor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.